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Finasteride and female hair loss were more prominent in the early follicular phases and, in particular, the early follicular phases of cycle. Male-headed mice, as well male DHT-treated (but not DHT-naïve) DMS mice were less susceptible to male-headed syndrome, and female-headed mice were more susceptible to female-headed syndrome. This latter study did not show a difference in hair and beard growth. general, it is difficult to extrapolate from animal studies human clinical trials. DHT also influences sexual differentiation in early embryonic development and is implicated in some forms of sexual differentiation later in life (5, 6). Testosterone treatment of female FGF15-transgenic mice with ovAR−/− reduced the expression of aromatase-related genes aromatase 3A (AREC3A) and 2 (AROM1), which convert testosterone to estradiol. These results suggest a role of testosterone in sexual development during early fetal development. Male DHT did not alter the expression of these genes when administered to FGF15-transgenic male mice or female mice, whereas males that received testosterone treatment in adolescence had decreased AROM2 gene expression and increased AREC3A relative to vehicle-treated males. Thus, early sexual differentiation of gonadally differentiated testicular germ cells may be influenced by both testosterone and estradiol. Studies that examined the effects of DHT on male-type Buy temazepam 10mg online facial appearance androgen receptor (AR) function in the mouse demonstrated decreased AR mRNA expression in the skin of male FGF15-transgenic mice during adolescence, as well increased mTFA mRNA expression. In contrast, only a small decrease in AR mRNA expression was found in skin of FGF15-transgenic female mice during adolescence and adulthood (5). However, AR mRNA expression remained unchanged after treatment with male testosterone (dissociated serum from aged animals) when administered to FGF15-transgenic male and female mice in adulthood, suggesting a role of endogenous testosterone in the regulation of hair and beard Order ultram overnight growth. In other studies, male DHT did not affect FGF18 mRNA expression and the number of hairs produced by AR−/− mice, although it reduced FGF18 mRNA expression when administered to young FGF15-transgenic female mice and aged male mice. However, in addition to changes hair length, skin thickness, and density, FGF18 mRNA expression was not affected in adulthood. These two studies illustrate that testosterone and DHT do not affect the expression of AR in skin (5) and that the observed changes in AR expression may involve a number of factors beyond testosterone production, including other estrogens. DHT also increases AR expression through a mechanism that is similar to of testosterone. For example, in cultured human keratinocytes, DHT promotes the translocation of AR from its native tissue site and increases AR-dependent protein synthesis in the epidermis and dermis (4). DHT promotes may induce the production of AR in female skin through both direct and indirect pathways. Female skin is thicker and more elastic in relation to its thickness than is male skin (7). Thus, DHT may promote androgen effects through its on the thickness and elasticity of female skin. Interestingly, although testosterone increases AR-dependent protein synthesis in female skin, it promotes only a modest increase in AR-dependent protein Diazepam 10mg 90 $260.00 $2.89 $234.00 synthesis androgen-independent tissues, such as muscle tissue (8, 9)
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